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The copper-binding tripeptide has been shown to stimulate collagen synthesis in fibroblast cell cultures, promote decorin and glycosaminoglycan production, and modulate expression of metalloproteinases (MMPs) involved in extracellular matrix remodeling in vitro

Before approving a new drug, the FDA typically requires companies to conduct a type of study called a randomized controlled trial, in which study participants are allocated by chance to groups that either receive the drug, or are administered a placebo

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and when administered by intranasal means varies between individuals with a mean of 46%