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Serine supplies glycine and one-carbon units for de novo nucleotide biosynthesis in proliferating T cells, and one-carbon units from formate can rescue T cells from serine deprivation ( We previously reported that calcium/calmodulindependent protein kinase IV (CaMK4) binds to PKM2 and promotes pyruvate kinase activity

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This shape change is possible because, unlike most other cells in the body, the human erythrocyte loses its nucleus and organelles before entering the circulation from the marrow

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