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The concentration was then adjusted to 0.2 M, and the excitation spectra (350 nm to 500 nm, fixed emission at 510 nm, bandwidth: 5 nm) were recorded in an FP-8500 spectrofluorometer (Jasco, Tokyo, Japan) at 25 C with continuous stirring for at least 1 min

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Results Effects of hyperforin on prostanoid formation in human whole blood Hyperforin was recently shown to inhibit the production of PGE 2 in LPS-stimulated RAW264.7 mouse macrophages (Hammer et al., 2 formation with an apparent IC 50 of approx

Through its activation of the phosphoinositol-3 kinase pathway and phosphorylation of the X-linked inhibitor of apoptosis protein (XIAP), IGF-1 acts to protect Kpffer cells and counter the potentially lethal effects of sepsis