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Therefore, BCAA metabolism manifests as a pleiotropic immunological arbitrator, where gut microbiota-driven metabolic reprogramming and host metabotype specificity converge to dictate its paradoxical roles across cancer immunotherapy and diabetic comorbidity, mandating precision metabologenomic approaches to harness its therapeutic duality while mitigating DM-associated oncogenic risk
10.1038/s41557-019-0261-6 [DOI] [PMC free article] [PubMed] [Google Scholar] 287.Lee, H
PMC 4729703
Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804
