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This realization suggested that, with proper medicinal chemical modifications, it may be possible to develop clinically useful small-molecule cognitive enhancers derived from Nle 1 -AngIV

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The human clinical data supporting AOD-9604 is limited compared to GLP-1 agonists

In WT and obese animals, AOD9604 reduces fat mass, increases 3-AR expression, enhances lipolysis, and stimulates energy expenditure and fat oxidation
