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10.21037/jtd.2019.10.43 50
This bacterium is unable to synthesize endogenous GSH as a cofactor for this enzyme but acquires GSH from host tissues via the GshT transporter
In theory, targeting any node of cysteine-GSH-GPx4 axis seems to be sufficient to induce ferroptosis
NO activates sGC, elevating cGMP levels, which, in turn, activate PKG
