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Some patients follow an initial loading phase over several weeks, then transition to a maintenance schedule if ongoing support is needed

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Using a similar strategy, exocyclic enones displaying antitumor activity were produced by a GSH-dependent reaction catalyzed by GST (Hamilton et al., 2002, 2003)

Closure and Interpretation The clinician interprets clinicalresponse patterns, laboratorytrend data, and adverseevent profiles to determine whether isotretinoin is providing sustained acnecontrol without unacceptable toxicity, then adjusts dose, duration, or adjunctive therapies as needed