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Low free and total plasma sulfate in children with autism has been previously reported in two studies [36, 37], and is consistent with four studies [36, 3840] which found that children with ASD had a significantly decreased sulfation capacity compared to controls, based on decreased ability to detoxify paracetamol (acetaminophen)

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Overall, existing evidence supports the pharmacological characteristics of ZSS, including multi-component synergy, multi-target regulation, and multi-pathway integration, and its direction of action is highly consistent with the current mainstream pathological hypothesis of depression

References 1 BersukerK.HendricksJ