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doi:10.1073/pnas.0900206106
20 It is worth noting that gene polymorphisms of liver metabolic enzymes, such as UGT , SULT , and CYP2E1 , and some co-existing diseases, such as viral hepatitis, acute and chronic malnutrition, and nonalcoholic fatty liver disease, may increase the susceptibility to APAP-induced liver injury, even at a therapeutic dose
Multi-site or diffuse injuries: Patients with two or more active injury sites, or with a diffuse pattern of soft tissue damage that is not localized to a single structure
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