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Likewise, the two consecutive serine residues (Ser462/Ser463 in EcGGT) of small subunit are replaced by histidine and threonine (414His/415Thr in GtGGT) in GGTs from extremophiles

The main limitation of this study is that it lacks a detailed estimate (by cardiac MRI) of the final infarct size compared to the initial area at risk to further reinforce these findings and provide a better comparison with animal data

For instance, miR-145-5p has been implicated in RGC apoptosis via the PI3K/AKT signaling pathway, highlighting the potential of modulating microRNA expression as a neuroprotective strategy (115)

However, studies that have investigated GABA B binding in the frontal cortex 61,62 and in the temporal cortex and hippocampus 62 found no evidence of altered GABA B -receptor binding, with the exception of an increased affinity in the temporal cortex of drug-free suicide victims