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A translationally robust strategy should therefore integrate screening of inhaled formulations and devices under conditions that capture this biological diversity, ensuring that therapies are effective across the real-world heterogeneity of patient airways

J Neurochem 104:113123 Czeredys M, Mysiorek C, Kulikova N, Samluk L, Berezowski V, Cecchelli R, Nalecz KA (2008) A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the bloodbrain barrier

These findings appear to be a result of disease and not other variables such as age or biological sex, as no significant difference in biological sex distribution within the cohort was found (Students t Test, p = 0.98) (Supplementary Data 1)

This upregulation exhausts intracellular GSH, leading to ROS buildup and oxidative DNA damage that can ultimately generate TP53 mutations, a process that is halted when CHAC1 is knocked down (Wada et al., 2018)