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[137] revealed that the accumulation of pro-inflammatory senescent stromal cells in mouse skin increased the presence of MDSCs and Tregs in mouse skin

ZWF1 stimulation by MEL has been suggested in a few studies, as activation of the enzyme glucose-6-phosphate dehydrogenase was observed in the presence of the molecule ( ZWF1 due to MEL under stress conditions observed in our study appears to highlight the importance of this gene in GSH recycling, as NADPH is a necessary cofactor for GR and provides reducing equivalents for redoxin systems

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE et al (2012) Ferroptosis: an iron-dependent form of non-apoptotic cell death

Thus, their clinical relevance in modulating CYC efficacy or toxicity remains unclear and warrants further investigation