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In the next step, a second equivalent of GSH reacts with the glutathionylated intermediate to form the stable product GSSG, and this allows the release of the reduced selenium or cystine for the next catalytic cycle (see Figure 4 for an example of GPX4 oxidoreductase mechanism)
Y., San, T
The test substance is considered non-mutagenic if at least one of the following criteria is met (Moore et al
Risk of lung cancer associated with domestic use of coal in xuanwei, china: retrospective cohort study
