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Quality of Individual Studies and Determination of Evidence Strength Quality of individual studies that were RCTs or crossover trials was assessed using the Cochrane Risk of Bias tool

Besides the aforementioned complex neuroendocrine interactions, a proper adrenal gland GC response during stress depends on the availability of cholesterol the major substrate for steroidogenesis [67], hereditary factors [68], and the crosstalk between multiple cell types coexisting in the adrenal microenvironment, such as adrenocortical, chromaffin, endothelial, neuronal, immune, and glial cells [69, 70]