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Genes that were significantly dysregulated after BDG exposure were clustered as (1) early and stable upregulation, (2) transient upregulation at 4 hours, (3) intermediate and stable upregulation, (4) late upregulation, (5) early and stable downregulation, (6) transient downregulation at 4 hours, (7) intermediate and stable downregulation, and (8) late downregulation ( Figure 2C and Supplementary Table 3A )