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Clinically meaningful responses in insulin-resistant patients typically include a reduction in fasting insulin of 20-40% and an improvement in HOMA-IR within 8-12 weeks at therapeutic doses, though individual variability is wide [1]
A time-dependent increase could be observed which was more pronounced in the targeted nanocarriers groups
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients
