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While vitamin C is quite possibly an effective substance, the amounts required for these therapeutic effects are obviously beyond dietary intakes

Vitamin E in dermatology, Pubmed

It is noteworthy that novel pharmacological interventions may be more effective in light of the compromised BBB in SE (171)

For instance, TYR staining was markedly reduced in the melanocytes of hair follicles with mild or moderate canities, despite strong TRP-1 expression in the same hair follicle (see supplementary figure 1)
