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28 Cells were grown in standard RPMI or treated with a dose of BSO lethal to SLC25A39 -knockout cells complemented with a guide-resistant SLC25A39 cDNA (Fig

Nanoparticles pass through biological barriers and interact with cell structures, which may cause either short-term or long-term damage (Figure 4) (193)

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Abbreviations 3-MST: 3-Mercaptopyruvate sulfurtransferase ALF: Acute liver failure AOAA: Aminooxyacetic acid CARS: Cysteinyl-tRNA synthetase CAT: Cysteine aminotransferase CBS: Cystathionine -synthase CNS: Central nervous system CO: Carbon monoxide CoQ: Coenzyme Q CSE: Cystathionine -lyase ETC: Electron transport chain ETHE1: Ethylmalonic encephalopathy 1 GalN: d-Galactosamine GSH: Glutathione GSSH: Glutathione persulfide H 2 S: Hydrogen sulfide HC: Hydroxocobalamin I/R: Ischemia/reperfusion LPS: Lipopolysaccharide MetHb: Methemoglobin NO: Nitric oxide O 2 : Oxygen PAG: dl-Propargyl glycine PLP: Pyridoxal 5-phosphate SDO: Sulfide dioxygenase SO: Sulfite oxidase SOU: Sulfide oxidation unit SQR: Sulfide quinone oxidoreductase STS: Sodium thiosulfate TNF-: Tumor necrosis factor TST: Rhodanese or thiosulfate sulfurtransferase References Reiffenstein RJ, Hulbert WC, Roth SH (1992) Toxicology of hydrogen sulfide