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Why Retatrutide Combinations Remain Unexplored Unlike cagrilintide, which Novo Nordisk has actively studied in combination with their GLP-1 agonist semaglutide, retatrutide has been developed primarily as a monotherapy by Eli Lilly [11]

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Extensive evidence suggests that development of optimized microbial chassis and the construction of synthetic microbial consortia, which integrate PET biodegradation through secreted hydrolases with the bioconversion of monomers into high-value chemicals, represents a highly promising strategy for achieving a circular economy in PET waste management (Wang et al., 2025