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While, olezarsen which is an N -acetylgalactosamineconjugated antisense oligonucleotide that targets APOC3 messenger RNA, is approved by both EMA and FDA, and it has reported that treatment with olezarsen resulted in significantly greater reduction in TG levels at 6 months than placebo among patients with moderate hypertriglyceridemia and elevated ASCVD risk 121
