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CPT1A and CPT1B at the outer mitochondrial membrane catalyze the first transport step of lipid metabolism, in which the long-chain acyl-CoA and carnitine are converted into long-chain acylcarnitine and CoA
It is induced by mutations in the gene encoding 3-hydroxysterol- 7 -reductase (DHCR7), the enzyme catalyzing cholesterol formation by 7-dehydrocholesterol reduction
doi: 10.1016/j.autrev.2020.102664
17 The ESR is elevated in obesity, as is CRP, presumably as a result of IL-6 secretion by adipocytes
