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I would say that our results suggest that defects that are caused by malfunctioning components of the eye, weve shown it most strongly for RGCs, but were starting to show it for other cell types such as the RPE layer in the eye

In addition to genetics, other hyperuricaemia/gout risk factors include: 1, 5, 6 Older age Male sex Obesity Cardio-metabolic co-morbidities, particularly CKD, hypertension and hyperlipidaemia Use of medicines that influence urate production, reabsorption or excretion, e.g

The retina is especially vulnerable to oxidative stress due to its high oxygen exposure and high concentration of polyunsaturated fatty acids
