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Studies that reflect the intended route, including deformable vesicles for insulin in animals and nanoparticle systems embedded in gels or films, show that residence time and interaction with the epithelium, rather than diffusion alone, determine the delivered dose in the oral cavity [124]

J Mol Cell Cardiol 81:114126 Li M, Chiu JF, Mossman BT, Fukagawa NK (2006) Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats

In vitro induction of sister-chromatid exchanges after G0 exposure of human lymphocytes to five naphthofurans
