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Why this matters: SIRT-1 Downstream Effects Stimulates caloric restriction and exercise pathways through these gene transcription factors:: PGC-1a: The core regulator of mitochondrial biogenesis, PPAR: Regulate fat oxidation, AMPK: Master regulator of cell energy, NF-kB: Inhibition leads to decreased inflammation and oxidative stress Clinical Studies Leucine-Resveratrol Synergy Human Pre-diabetic Subjects Randomized: Leucine 1.1 g + Resveratrol 50mg Twice Daily vs

J Biol Chem 278:4155241556 Cao J, Barbosa JM, Singh NK, Locy RD (2013) GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing the production of reactive oxygen species