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Description
no therapeutic intervention trials published Cell culture Skeletal muscle myoblasts, cardiomyocytes, endothelial cells, fibroblasts, mesenchymal stem cells Ex vivo tissue preparations Isolated mitochondria, cardiac tissue preparations for respiration studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 100 published preclinical studies and growing scientific interest, MOTS-c faces substantial translational barriers that limit clinical application and necessitate cautious interpretation of its therapeutic potential
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14,21 Epidemiological evidence has indicated 54% of U.S
The 5-session protocol outperformed a previous 3-session protocol (26.5% vs 10%, p = 0.0025)
