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Description
Nrf2 is a transcription factor that regulates the expression of antioxidants and anti-inflammatory genes
Pathways regulating ferroptosis in AD Kelch-like ECH-associated protein 1 (Keap1)/Nrf2)/antioxidant response element (ARE) pathway In cellular defense against oxidative stress, the Keap1/Nrf2/ARE signaling pathway regulates the expression of various proteins involved in detoxification and antioxidant defense, positioning it as a potential target for AD treatment (61)
It was demonstrated in in vitro experiments that OGD effectively induced the death of ADSCs
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