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Efficacy for skin lightening remains unproven in clinical trials

No financial benefits from the data is anticipated, the data will be used to help prevent and treat those to whom the data applies

After centrifuging, the supernatant was collected, and the commercial enzyme linked immunosorbent assay (ELISA) kits were used to measure the concentration of C-reactive protein (CRP) (Jiancheng Bioengineering Institute, Nanjing, Jiangsu, China) and anti-Collagen II antibody (anti-CII) (Fankew, Shanghai, China) in plasma according to the instructions

Moreover, we also observed the accumulation of kynurenine (Kyn), which is a product of tryptophan catabolism (Aune and Pogue 1989) and regulator of the PPP (Fabregat et al