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In fact, exposure to heavy metals such as mercury, cadmium, lead, or arsenic can also lead to glutathione depletion

PKC-mediated phosphorylation of p47phox, a cytosolic NOX subunit, facilitates its translocation to the membrane, where it associates with gp91phox (NOX2) and p22phox, forming the catalytically active oxidase

The core reactions of glutathione synthesis are conserved across various organisms, but plants have diversified both the regulatory mechanisms that control its synthesis and the range of products derived from this pathway

393, 223230.10.1016/S0014-2999(99)00888-2 210 QuikM.ParameswaranN.McCallumS