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By contrast, signalling via TrkB has been largely considered to protect neurons antagonizing the NMDAR-mediated excitotoxic cell death

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A.VafaevaO.et al (2021)

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Further investigations were, however, performed on the most active series using a genetic approach based on RNA interference and highlighted a potential multi-target mechanism of action through topoisomerase II, mitotic spindle, HDAC and DNMT inhibition

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