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Several mechanisms have been implicated leading to Vit B12 deficiency, HHcy and increased levels of MMA ( Fig

References For general education only not medical advice or a treatment recommendation

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While vitamin B 12 deficiency is not a primary test in newborn screening programs, a study showed that markers C3, C3/C2, and C3/C16 exhibit a negative correlation with maternal levels of vitamin B 12 in the first trimester of pregnancy, and thus may bear diagnostic value (Dayaldasani et al., 12 insufficiency or deficiency during the first trimester of pregnancy and adequate treatment