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In contrast, astrocytes exhibit lower expression of pyruvate dehydrogenase (Laughton et al., 2007), which limits oxidative phosphorylation (Itoh et al., 2003) and reduces pyruvate utilization efficiency in the TCA cycle (Rahman et al., 2020)
These results suggest that IGF-1R activation in the retina may occur through IGF-1 produced outside the liver
Askari M, Faryabi R, Mozaffari H, Darooghegi Mofrad M
Gadhave D, Rasal N, sonawane R, Sekar M, Kokare C
