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[DOI] [PubMed] [Google Scholar] 56.Lerman A, et al

192 EVs and Exos can also interact with lncRNAs

This difference in efficiency is in line with the improved cellular uptake of phenformin over metformin and the much lower typical therapeutic dosage of phenformin compared to metformin in humans 68

Certain tumor-derived chemokines such as CCL21 can activate LECs and increase the expression of adhesion molecules (78, 97) ( Figure 3A )