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Similarly, caspases and the anti-apoptotic Bcl-2 protein have been shown to be nitros(yl)ated (PSNO) under basal conditions in human lung epithelial cancer cells, and their denitros(yl)ation is necessitated for their activation during apoptosis [77]
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The engineering involves three key modifications
This makes albumin bind, which increases the plasma half-life to about 170 hours
