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Description
This was fully investigated in 1849, by British physician Thomas Addison, from which it acquired the common name of Addison's anemia

333ZouAPCowleyAWJr Reactive oxygen species and molecular regulation of renal oxygenation

As an underlying mechanism, genistein appears to inhibit oxidative stress-stimulated c-Src kinase activation, preventing the tyrosine phosphorylation of TJ proteins (ZO-1 and occludin) and adherence junction (AJ) proteins (E-cadherin)

"Designing Formulation Strategies for Enhanced Stability of Therapeutic Peptides in Aqueous Solutions: A Review." Pharmaceutics , 2023
