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Clinical data shows benefits fade within 2-6 months despite maintenance therapy, with only 6.2% of patients retaining any effect at 6 months in the Zubair et al

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For instance, a single-center study involving 200 type 2 diabetes patients, stratified by UACR categories (normal, micro-, and macroalbuminuria), found that the combined measurement of C16, C18:1, and C3 achieved an area under the receiver operating characteristic curve (AUC) of 0.89 for early DKD diagnosis, significantly outperforming UACR (AUC = 0.76) [147,148,149,150]