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The abnormal expression of GPx2 was detected in different tumors, and GPx2 was up-regulated in colorectal cancer [51, 52] and down-regulated in prostate intraepithelial neoplasia [53], suggesting that GPx2 plays complex roles in tumorigenesis [23]

Silybum marianum has been used in western herbal medicine as a hepatoprotective and antioxidant

Chronic inflammation leads to the secretion of cytokines that sustain inflammation and redox stress, inducing mitochondrial DNA (mtDNA) damage (19)

Sekhar, R.V., McKay, S.V., Patel, S.G., Guthikonda, A.P., Reddy, V.T., Balasubramanyam, A
