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Purification of ascorbate peroxidase in spinach chloroplasts: its inactivation in ascorbate-depleted medium and reactivation by monodehydroascorbate radical

Possible involvement of DNA methylation in 5-azacytidine-induced neuronal cell apoptosis

ALP catalyzed the hydrolysis of the weak fluorescent 2-(2-benzothiazoyl)-6-hydroxybenzothiazole phosphate into a strong fluorescent 2-(2-benzothiazoyl)-6-hydroxybenzothiazole (Scheme 2)

The change induces difficulty in repairing ruptures of double-stranded DNA, increases ROS production, mitochondrial dysfunction, with concomitant oxidative stress and consequent cell apoptosis [10, 11]