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Its ability to reshape the tumor microenvironment while augmenting responses to checkpoint inhibitors underscores its therapeutic potential particularly when combined with other cancer immunotherapies establishing it as a formidable agent in anti-tumor immunity

Seven days after TDM introduction, CD11b + CD45 + macrophages with high surface expression of M1 (inflammatory)-like markers CD38 and CD86 were found in the pathological areas of mouse lung tissues ( Effect of CD38 on Macrophage Proliferation and Polarization Macrophages exert an effector function against invading microorganisms

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Al-Yozbaki, M., Acha-Sagredo, A., George, A., Liloglou, T., & Wilson, C