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Healthy cells generally have a GSH/GSSG ratio of greater than 100, while cells under oxidative stress exhibit a ratio of about 1:10substantially lower

Neurologic manifestations are caused by progressive demyelination and can include peripheral neuropathy, areflexia, and the loss of proprioception and vibratory sense

These processes have been described in the healing of tendons, muscles, and skin wounds, suggesting that the mechanism of action is not limited to a specific tissue type but rather involves general cellular regulatory pathways

The diurnal secretory pattern of GH in human is fully developed after puberty, demonstrating a major peak at late night/early morning which is associated with NREM (slow wave)-sleep, and a number of peaks during the light hours of the day, but with quite large individual difference (456)