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"Obesity drugs in clinical development." Current Opinion in Investigational Drugs 7.4 (2006): 312

NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1

This achieves subcellular targeting of therapeutics (e.g., PUE), mitigating MIRI-associated mitochondrial impairment

Recent advances in the role of mesenchymal stem cells as modulators in autoinflammatory diseases [J]
