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In addition, numerous studies have shown that the incidence of MACEs in heart failure patients with atherosclerosis can be significantly reduced by lowering LDL-C levels for other lipoproteins, such as LDL [99, 100]

Several subclasses of these former T-regs have been identified in the atherosclerotic lesions of mice, including Th1-Tregs (CD4 + CCR5 + IFN- + FoxP3 + T-bet + ) and T follicular helper cells (CXCR5 + PD1 + Bcl6 + CD62L lo CD44 hi CD4 + Foxp3 - ), and these have been shown to have both impaired regulatory and enhanced inflammatory function, therefore contributing to atheroprogression (91,92)

Patients In CD patients (group A), inclusion criteria were as follows: (1) diagnosis of CD according to conventional criteria