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10.1007/s00421-020-04354-0 106 NakamuraY.AizawaK

Methionine in the form of S-adenosylmethionine (SAM) is required for many methylation reactions, including DNA methylation

This panel might include other enzymes and proteins made by your liver, such as: Alanine transaminase (ALT) Alkaline phosphatase (ALP) Bilirubin Total protein If your results are abnormal, your doctor might recommend follow-up testing

Thus, NAC has multiple modes of action against acetaminophen-induced hepatotoxicity, which helps explain why NAC is beneficial, even if administered with significant delay after the overdose in patients [62] and human hepatocytes [55]