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Isocitrate lyase (ICL) inhibitors ICL plays a crucial role in mycobacterial glyoxylate and methyl isocitrate cycles, which are essential for M.tb survival, virulence [100], and antibiotic tolerance [101]

761 The overexpression of CYP1B1 increases the ubiquitination and degradation of ACSL4, and melatonin could inhibit ferroptosis by regulating the ACSL4/CYP1B1 pathway, significantly reducing the cerebral ischemic area and neuron loss in MCAO mice

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When assayed with ultrafiltered flavan-3,3,4-triol ( 4 ), oxidation of C13 in the wild-type enzyme resulted in a drastically lower formation of cyanidin ( 8 ), while we observed no effect for the C13S variant (Fig