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From the structural and functional points of view, it is reasonable to conclude that the two ERs interact with the same DNA response elements and have similar binding affinities for 17-estradiol (E2) (Kuiper et al ., 1997)

[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Yang Y.M., Huang A., Kaley G., Sun D

Its opposing roles, i.e., its ability to suppress autophagy in cancer and cardiac disease while enhancing it in neurodegeneration, reveal its complex, tissue-specific regulatory capacity

[DOI] [PubMed] [Google Scholar] 54.imek M., Turkov K., Schwarzer M., Neporov K., Kubala L., Hermannov M., Foglov T., afrnkov B., indel M., rtkov D., et al
