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For instance, histidine has been implicated in hydroxyapatite mineralisation in vitro , and its circulating levels, along with alanine, arginine, lysine and glutamine, have been associated with fracture risk reduction [31, 32]

The S2 subsite is also sufficiently deep to accommodate a larger side chain and is lined by the side chains of Lys208, Arg220 and Thr222 from the N-terminal barrel and Phe673 from the C-terminal barrel

Indian Journal of Endocrinology and Metabolism

J Child Neurol 19:413417 Paca SP, Neme B, Vlase L, Gagyi CE, Dronca E, Miu AC, Dronca M (2006) High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism