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SAMe depletion decreases the methylation capacity of the cell, indicated by the SAMe/SAH ratio, producing a reduction of CpG islands methylation and global DNA hypomethylation that leads to aberrant gene expression and compromises genomic stability [63]

Chasin believes strongly that the best cosmetic physicians are those who are dedicated to mastering their craft through continuing education and collaboration with the industrys top doctors.

Biomed Chromatogr 2009;23:658-64
