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Systemic neurological conditions also drive chronic muscle spasms: multiple sclerosis (MS), peripheral neuropathy, amyotrophic lateral sclerosis (ALS), and restless legs syndrome all disrupt the normal nerve-to-muscle communication pathway, producing involuntary contractions that can affect the entire body

[DOI] [PubMed] [Google Scholar] 55.Kalderon B, Mayorek N, Berry E, Zevit N, Bar-Tana J