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doi: 10.4103/1008-682X.153850
IGF-1 LR3 was developed at GroPep Limited (Adelaide, Australia) and originally characterized by Francis and colleagues in The Journal of Molecular Endocrinology , who reported that the modified analog showed enhanced biological potency relative to native IGF-1 in cell-culture systems and that the enhancement was attributable to reduced binding to IGFBPs rather than to changes in IGF receptor affinity [1]
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