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This process can be compared to the establishment of ploidy in humans, as all hepatocytes are diploid in neonates and approximately 40% of hepatocytes are polyploidy by late teens, these processes all take time

Nuclear transport and cancer: from mechanism to intervention

Daly K, Al-Rammahi M, Moran A, Marcello M, Ninomiya Y, Shirazi-Beechey SP

111 SakagamiH.ShengH.OkudairaN.YasuiT.WakabayashiH.JiaJ.et al (2016)
