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IL-6 -/- mutant mice exposed to the same cytokine storm-inducing stimuli exhibited improved lung function, decreased edema, decreased lung pathology on hematoxylin/eosin stain as compared to wild-type specimens
On the other hand, the activation of STAT3 induced the expression of IGF-1R [51] indicating that the cytokine-mediated JAK/STAT3 pathway was able to sensitize insulin/IGF-1 signaling
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